Extended Data Fig. 8: Analysis of the β1 catalytic triad.
From: Mechanism of autocatalytic activation during proteasome assembly
Arg38 in β1 shows a similar orientation to the corresponding arginine residues in β5 and β2, and is hydrogen bonded (dashed lines) to the triad aspartate and lysine residues, suggesting that it may play an important role in β1 activation. However, unlike the situation in β5 and β2, β1′s Arg38 does not form a salt bridge or even contact its midline partner, β7, suggesting that additional mechanisms may account for β1 activation.
