Extended Data Fig. 5: Map quality of regions in Gβγ-bound PI3Kγ structures.
From: Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
(A)-(C) Local resolution estimation for PI3Kγ·ADP–GβγHD, as well as states 1 and 2 of PI3Kγ·ADP–GβγHD–GβγCTD. (D)-(F) Visualization of sidechain density of residues in the p110γ subunit of PI3Kγ·ADP–GβγHD, and states 1 and 2 of PI3Kγ·ADP–GβγHD–GβγCTD. p110γ-C2-Tyr389 and p110γ-HD-Trp598 are labeled. (G)-(I) Overlay of maps and models showing the interfaces between p110γ-HD and -K domains in PI3Kγ·ADP–GβγHD, and states 1 and 2 of PI3Kγ·ADP–GβγHD–GβγCTD. Leu564 is indicated. (J)-(L) Overlay of maps and models showing the interfaces between the p101-CD and -CTD domains in PI3Kγ·ADP–GβγHD, and states 1 and 2 of PI3Kγ·ADP–GβγHD–GβγCTD. p101-Ile689 is indicated.
