Extended Data Fig. 10: Cryo-EM reconstruction of PI3Kγ·ATP.
From: Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
(A) Cryo-EM map of PI3Kγ·ATP. Domains are colored as in Fig. 1a. (B) Superimposition of PI3Kα·diC4-PIP2 (PDB entry 4OVV, in yellow) with PI3Kγ·ATP (in black) indicates a steric clash between the PIP2 substrate and α36. diC4-PIP2 and ATP in PI3Kγ·ATP are shown as green and red spheres, respectively. The p110γ-RBD, K-N, and K-C domains are located in Areas 1, 2, and 3.
