Extended Data Fig. 4: Integrator depletion leads to the upregulation of unbiased bidirectional transcription in the enhancer RNA loci.
From: Transcription directionality is licensed by Integrator at active human promoters
a. Enhancer and Super enhancer distribution map calculated by RNAPII ChIP-seq signal in units of reads per million. Enhancers are ranked by the increase in the RNAPII ChIP-seq signal. b. IGV tracks of a super-enhancer locus from ChromRNA-seq and RNAPII ChIP-seq results before and after INTS11 depletion. c. IGV tracks of ChromRNA-seq, 4sU-seq, and TT-seq of two enhancer RNA loci. d. Heatmap of 3,259 enhancer loci. from ChromRNA-seq and 4sU-seq results. e. Metagene analysis showing the average occupancy of ChromRNA-seq and 4sU-seq signals at 3259 enhancer RNA loci.
