Extended Data Fig. 7: A Nse3 loop involved in the binding of the Smc5 head region in the Smc5/6-6mer structure.
From: Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
(a) Superimposition of the head regions of the Smc5/6-6mer structure obtained in this work and reported previously (PDB: 7QCD). (b) A Nse3153-172 loop with clear density map observed in the current Smc5/6-6mer structure (top and middle) was not resolved in the report structure (bottom; PDB: 7QCD). (c) The Nse3153-172 loop shows interaction with Nse1 and the Smc5 head region in the Smc5/6-6mer structure reported here (top). The residues involved in the interaction are in dark blue and are listed in the table (bottom). (d) The Nse3153-172 loop is seen in both the Smc5/6-6mer structure (color) and the Nse1-3-4 structure (gray) reported here. (e) The Nse3153-172 loop is near the ATP binding site of Smc6.
