Extended Data Fig. 5: Per-state violin-plots for the residue-residue distance-distributions of L394α5 with the TM6 lysine ladder K2676.29, K2706.32, and K2736.35.
From: Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor
K273 (bottom right), which lies deepest in the G protein binding pocket of the receptor, has the most contact for state A, the β2AR-GsGDP intermediate, whereas there is none in β2AR-Gsempty. All violins have been normalized to the same width. The number of samples behind each violin are 3499, 859, 2876 and 992 for State A, State B, State C and State β2AR-Gsempty, respectively.
