Extended Data Fig. 1: Sequence alignment and conservation of human SV2s.
From: Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants
a. Alignment of the SV2 protein family, showing absolutely conserved residues in green, SV2A disease associated mutants in red, conserved residues involved directly in binding UCB-2500 or PSL in purple, and non-conserved residues involved directly in binding UCB-2500 or PSL in pink or blue. b. ConSurf analysis of SV2A, with most conserved residues in maroon and least conserved residues in turquoise. c. ConSurf analysis of SV2B, with most conserved residues in maroon and least conserved residues in turquoise.
