Extended Data Fig. 3: Comparison of the METTL6-SerRS-tRNASer interfaces between the reconstructed 3D classes.
Final EM map of a 1:2:2 complex at 2.4 Å resolution and represented at level 0.3. b 2:2:2 complex at 3.7 Å resolution and represented at level 0.162. c 1:2:1 complex at 4.2 Å resolution and represented at level 0.168. All are coloured as in Fig. 1c, with the methyltransferase core of METTL6 coloured in light orange and the RNA binding domain (m3C-RBD) in dark orange. The N-terminal domain (NTD) of SerRS is coloured in dark purple and the aminoacylation domain (AD) in light purple. The second SerRS protomer NTD is coloured in salmon and the AD in light pink.; tRNA is coloured in black.
