Fig. 2: Structure of XlHAS1.
From: Structural insights into translocation and tailored synthesis of hyaluronan
a, Representative 2D class averages and electron potential map of XlHAS1. The map was contoured at σ = 9 r.m.s.d. (root-mean-square deviation) and is overlaid with an ab initio volume to visualize the detergent micelle. b, Domain organization of XlHAS1 and Fab-binding site. c, Architecture of XlHAS1. The catalytic domain, amphipathic IFHs and transmembrane regions are colored blue, light pink and pink, respectively. d, Surface representation of XlHAS1 indicating a curved channel with lateral pathway. e, Cartoon representation of XlHAS1 highlighting the positions of the N-terminal extension and the unresolved gating loop above the active site (dashed line).
