Extended Data Fig. 6: Cryo-EM structure of the α-syn fibrils in complex with RNA PolyA. | Nature Structural & Molecular Biology

Extended Data Fig. 6: Cryo-EM structure of the α-syn fibrils in complex with RNA PolyA.

From: Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides

Extended Data Fig. 6

a, Top and side views of the cryo-EM density map of the PolyA-Polymorph 1 fibril. The PolyA densities are colored in orange. b, Cross-section view of the structural models of PolyA-Polymorph 1 fitted in the density map. Structural model is colored in grey. The density map is restricted to areas within 2-Å radius of the α-syn model, and combined with the PolyA densities colored in orange. The PolyA binding site is zoomed-in. c, Zoomed-in view of the interactions between PolyA and α-syn at the binding sites of PolyA-Polymorph 1. d, Density map of PolyA-Polymorph 2 fibril, shown as in panel a. e, Structural model of PolyA-polymorph 2 fitted in the density map, shown as in panel b. f, Interactions between PolyA and α-syn in PolyA-polymorph 2.

Back to article page