Extended Data Fig. 7: Cryo-EM structures of the α-syn fibrils in complex with CS and PolyP. | Nature Structural & Molecular Biology

Extended Data Fig. 7: Cryo-EM structures of the α-syn fibrils in complex with CS and PolyP.

From: Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides

Extended Data Fig. 7

a, Top view and side views of the cryo-EM density maps of the CS-bound α-syn fibrils. The additional densities for CS are colored in orange. b, Cross-section view of the structural model of CS-bound α-syn fibrils fitted in the density maps. The model is colored in grey. The density maps are restricted to areas within 2-Å radius of the α-syn model, and combined with the CS densities colored in orange. The models and maps at heparin binding sites are zoomed-in. c, Overlay of 1-layer α-syn structures in the apo- (grey) and CS-bound α-syn fibrils (pink). The structural models are shown in sticks. Flipped residues are zoomed-in. d, Top view and side views of the cryo-EM density maps of the PolyP-bound α-syn fibrils. The additional densities for PolyP are colored in orange. e, Cross-section view of the structural model of PolyP-bound α-syn fibrils fitted in the density maps. The model is colored in grey. The density maps are restricted to areas within 2-Å radius of the α-syn model, and combined with the PolyP densities colored in orange. The models and maps at heparin binding sites are zoomed-in.

Back to article page