Extended Data Fig. 1: Cryo-EM 2D averages, 3D density maps, and resolution estimation of the apo and heparin-remodelled α-syn fibrils. | Nature Structural & Molecular Biology

Extended Data Fig. 1: Cryo-EM 2D averages, 3D density maps, and resolution estimation of the apo and heparin-remodelled α-syn fibrils.

From: Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides

Extended Data Fig. 1

a. Cryo-EM 2D class averages of the apo α-syn fibrils and heparin-remodelled α-syn fibrils. The lengths of half pitch for each fibril are indicated. b. Central slices of the cryo-EM 3D maps of the apo and heparin-remodelled α-syn fibrils. c. The overall resolution estimates are calculated based on the gold-standard 0.143 Fourier shell correlation (FSC) of the two independently refined half-maps. d. Top views (left) and side views (right) of the local resolution plots of the recombinant density maps.

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