Extended Data Fig. 3: Conserved additional densities on the ex vivo α-syn fibrils from MSA and heparin-remodeled α-syn fibrils. | Nature Structural & Molecular Biology

Extended Data Fig. 3: Conserved additional densities on the ex vivo α-syn fibrils from MSA and heparin-remodeled α-syn fibrils.

From: Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides

Extended Data Fig. 3

a, The structural models of the MSA α-syn fibril fitted in the density map. α-Syn is colored in gray. The additional densities adjacent to lysine residues are shown in red and zoomed in. b, Overlay of the α-syn subunit structures in the heparin-remodeled α-syn fibrils (blue) and ex vivo MSA α-syn fibrils (grey). Residues K58 and K60 are shown in sticks. The conserved additional densities are indicated by pink ovals. Root Mean Square Deviations (RMSDs) are shown at the bottom.

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