Extended Data Fig. 6: Structural comparisons of the ion conductance pathways and M1 & M2 sites of the closed states of CtMrs2 and TmCorA. | Nature Structural & Molecular Biology

Extended Data Fig. 6: Structural comparisons of the ion conductance pathways and M1 & M2 sites of the closed states of CtMrs2 and TmCorA.

From: Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism

Extended Data Fig. 6

The figure was generated using alignment of the YGMN-motifs. CtMrs2 is shown in blue with Mg2+ at M1 and M2 as green spheres. TmCorA (PDB-ID 3JCF) is shown in pink with Mg2+ at M1 and M2 as yellow spheres. Residues lining the pore are shown as sticks and the approximate pore lengths are indicated. a, Overall view. b, Close-view of the gate residues for TmCorA and CtMrs2. c, Close-views of the M1/2 binding sites from the cytoplasm and mitochondrial matrix of TmCorA and CtMrs2, respectively.

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