Extended Data Fig. 10: The open state of CtMrs2. | Nature Structural & Molecular Biology

Extended Data Fig. 10: The open state of CtMrs2.

From: Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism

Extended Data Fig. 10

a, 3.2 Å overall resolution cryo-EM density of the CtMrs2 homo-pentamer (using C5 symmetry). The views are from the intermembrane space and from the matrix, respectively. The monomer are colored in blue, orange, wheat, green and pink. b, Cartoon representation of the CtMrs2 homo-pentamer with same views as in panel a and colored as in panel a. c, Comparison of two uncropped reconstructed cryo-EM maps, calculated in the absence of symmetry (C1, grey) or with C5 symmetry (yellow) imposed. The views are from the side, from the intermembrane space and from the matrix. The two maps overlay well. The Mg2+ bound to GMN-motif selectivity filter is shown as a green sphere.

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