Extended Data Fig. 6: TK1 promotes tumor growth with elevated dTMP. | Nature Structural & Molecular Biology

Extended Data Fig. 6: TK1 promotes tumor growth with elevated dTMP.

From: ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth

Extended Data Fig. 6

(a, b) Huh7 cells with or without endogenous TK1 depletion and reconstituted expression of the indicated Flag-rTK1 proteins were subcutaneously injected into 6-week-old male athymic BALB/c nude mice, n = 5 per group. Tumors were shown in (a). Tumor weight (b, Left), and tumor volume (b, Right) were measured. Data represent means ± SD, analyzed by one-way ANOVA (b, Left) or two-way ANOVA (b, Right). (c, d) Huh7 cells with or without endogenous USP9X depletion and reconstituted expression of Flag-TK1 KEN-KAA proteins were subcutaneously injected into 6-week-old male athymic BALB/c nude mice, n = 5 per group. Tumors were shown in (c). Tumor weight (d, Left), tumor volume (d, Right) was measured. Data represent means ± SD, analyzed by one-way ANOVA (d, Left) or two-way ANOVA (d, Right).

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