Extended Data Fig. 6: THIK1EM electrostatic surface potentials.

a, Electrostatic surface potentials calculated using APBS105. Side, cytoplasmic, and extracellular views are shown. b, Slice through the center of K2P13.1EM showing the inner cavity. Selectivity filter ions are shown as purple spheres. Location of Tyr273 is indicated. One subunit is shown as transparent. Select channel elements are labeled. Grey bars denote the membrane.