Extended Data Fig. 8: Structural comparison of THIK1EM S136P in nanodiscs and detergent micelles. | Nature Structural & Molecular Biology

Extended Data Fig. 8: Structural comparison of THIK1EM S136P in nanodiscs and detergent micelles.

From: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site

Extended Data Fig. 8

Superposition of THIK1EM S136P:DDM:CHS:GDN, THIK1EM S136P:Det (deep blue) and THIK1EM S136P:Nanodisc, THIK1EM S136P:ND (cyan) structures showing a, side and b, cytoplasmic views. c, Comparison of THIK1EM S136P:ND (cyan) and THIK1EM S136P:Det (deep blue) flow restrictor regions. Distances between Tyr273 hydroxyl oxygens are indicated. Linoleic acid (EIC) is shown in space filling. d, and e, Selectivity filter and flow restrictor densities (7-7.5σ) for d, THIK1EM S136P:ND (cyan) and e, THIK1EM S136P:Det. Select residues are labeled.

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