Fig. 1: Cryo-EM structure of fascin cross-linking actin filaments.
From: Fascin structural plasticity mediates flexible actin bundle construction
a, Diagram of F-actin’s helical architecture. Model generated from PDB 7R8V. b, Left, schematic of end-on and side views of a fascin-cross-linked F-actin array. Actin filaments are shown in blue and fascin cross-bridges at each diagonal are depicted as colored lines. Right, side view of an actin plane (box in left panel) featuring a slanted fascin cross-band. c, Schematic of a fascin-cross-linked hexagonal bundle element. d, Domain architecture of human fascin-1. e, Composite 3.1-Å resolution cryo-EM density map of fascin-cross-linked F-actin. f, Atomic model of fascin-cross-linked F-actin in ribbon representation.
