Fig. 2: Fascin rearrangements upon F-actin binding are allosterically blocked by G2.
From: Fascin structural plasticity mediates flexible actin bundle construction
a, Superposition of fascin in the prebound (PDB 3LLP) and F-actin bound states. b, Superposition of fascin in the prebound and inhibitor-bound (PDB 6B0T) states. The inhibitor NP-G2-029 is highlighted in space-filling representation. c, Superposition of fascin in the inhibitor-bound and F-actin bound states. d, Detail view of boxed region in c highlighting clash that would occur between NP-G2-029 and β-trefoil 1 in the F-actin bound state. All structures are aligned on β-trefoil 2.
