Extended Data Fig. 6: Conformational change of switching loop upon compound binding. | Nature Structural & Molecular Biology

Extended Data Fig. 6: Conformational change of switching loop upon compound binding.

From: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30

Extended Data Fig. 6

a-h, Structural superpositions showing the switching loop positions in different USP DUBs, comparing compound-bound to ubiquitin-bound or apo states (a: USP30 with NK036 compared to Ubiquitin-bound USP30, b: USP7 with GNE6776 compared to apo USP7, c: USP14 with IU1-206 compared to apo USP14, d: USP28 with FT206 compared to apo USP28, e: USP1 with ML323 compared to Ubiquitin-bound USP1, f: USP7 with compound 2 compared to Ubiquitin-bound USP7, g: USP14 with IU1-206 compared to Ubiquitin-bound USP14, h: USP7 with compound 23 compared to Ubiquitin-bound USP7).

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