Extended Data Fig. 1: Small molecule inhibitors of USP30. | Nature Structural & Molecular Biology

Extended Data Fig. 1: Small molecule inhibitors of USP30.

From: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30

Extended Data Fig. 1

Chemical structures of representative examples of small molecule USP30 inhibitors are given together with characterization data and references. Cyanamides of covalent inhibitors form isothiourea linkages with the active site cysteine of USP30. Non-covalent inhibitors belong either to chemical series which were developed from phenylalanine derivatives (with either a benzenesulfonamide or a naphthylsulfonamide) or are natural product derivatives.

Back to article page