Extended Data Fig. 7: Specifics of Lis1 interaction with dynein.
From: Multiple steps of dynein activation by Lis1 visualized by cryo-EM
a. Comparison of models build for bent linker dynein bound to 2x Lis1 β-propellers (B8, blue, Lis1 – gray) with bent linker dynein bound to 1x Lis1 β-propellers (B7, white, Lis1 – white). The two Lis1 binding sites are highlighted and shown to the right. b. Comparison of models build for intermediate linker dynein bound to 2x Lis1 β-propellers (I7, green, Lis1 – gray) with intermediate linker dynein bound to 1x Lis1 β-propellers (I6, white, Lis1 – white). The two Lis1 binding sites are highlighted and shown to the right. c. Comparison of models build for bent linker dynein bound to 2x Lis1 β-propellers (B8, blue, Lis1 – white) with intermediate linker dynein bound to 2x Lis1 β-propellers (I7, green, Lis1 – white). The two Lis1 binding sites are highlighted and shown to the right.
