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Chromatin

The yin yang of transcriptional memory

Transcriptional memory is a phenomenon that enables cells to memorize transient gene activation. A study now sheds light on epigenetic mechanisms conveying mitotic-heritable memory in the context of the IFNγ model.

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Fig. 1: Regulators of transcriptional memory of the GBP gene cluster upon IFNγ reinduction.

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Correspondence to Effie Apostolou.

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Laguillo-Diego, A., Apostolou, E. The yin yang of transcriptional memory. Nat Struct Mol Biol 32, 1132–1134 (2025). https://doi.org/10.1038/s41594-025-01574-w

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