Extended Data Fig. 6: Modelling of RNA into the active site of CtTrl1-LIG.
From: Structure of fungal tRNA ligase Trl1 with RNA reveals conserved substrate-binding principles
a, Overview of RNA binding amino acids in CtTrl1-LIG (based on ASL-RNA modeling in Fig. 4a) as well as the corresponding residues in yeast (ScTrl1). Amino acid residues of the CTD are colored in light blue. The cell viability of the respective alanine variants in S. cerevisiae is indicated based on this study or in42. b, Mode 1 of Principal Component Analysis illustrates the clamping motion of the protein toward the tRNA. The green arrows indicate the movement directions.
