Extended Data Fig. 10: A bursting regime with a minimal ON-OFF cycle recapitulated the data.
From: A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics
An ON-OFF transcriptional regime, with a lower limit on these period durations and a minimal mean burst cycle duration \({T}_{{\rm{ON}}}+{T}_{{\rm{OFF}}}=1/F\) shown in red, closely recapitulates the observed bursting relationships in black. The horizontal dotted line corresponds to a lower bound of 1.8 min providing the best-fit to the data. An allele at mid-activity level (PON = 0.5) minimizes \({T}_{{\rm{ON}}}+{T}_{{\rm{OFF}}}\). Various ON-OFF combinations can yield \({P}_{{\rm{ON}}} > 0.5\), but increasing OFF periods prolong encoding PON compared to solely increasing ON durations.
