Extended Data Fig. 2: 48 h time course following treatment with CBQ at 20hpi. | Nature Structural & Molecular Biology

Extended Data Fig. 2: 48 h time course following treatment with CBQ at 20hpi.

From: Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Extended Data Fig. 2

Hema3-stained blood smears of highly synchronized early trophozoite-stage P. falciparum parasites, taken at 0, 1, and 3 h after addition of DMSO, CBQ, or CHX at 20hpi, and every 4th hour after, out to 48 h. Three biological replicates were performed, with n = 25-81 for each time point in each replicate. One representative replicate is shown. Time of drug addition at 20hpi and time points corresponding to those used in our in situ cryoET studies are indicated with a green and black arrowheads, respectively. Box with a bold pink outline indicates a pyknotic cell.

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