Extended Data Fig. 3: Reproducibility between independent clones for all tested rearrangements; additional data of deletion series.
From: Interactions between the genome and the nuclear lamina are multivalent and cooperative
(a) Correlations between the two independent recombined or Cas9-edited clones for each tested rearrangement, calculated as the Pearson correlation coefficient of the changes in pA-DamID score (Experimental minus Control), for windows of 123 kb. (b-e) Domainogram (top) and pA-DamID tracks (bottom) of CAST (left) and 129S1 (right) allele NL interactions comparing non-recombined (“Control”, blue) and recombined (“d2” (b), “d3” (c), “d4” (d) and “d5” (e), red) cells from recombination d2 (b), d3 (c), d4 (d) and d5 (e). pA-DamID tracks and domainograms are plotted on the WT chromosomal coordinates. Domainogram colour-key in (b) applies to all panels. (f) pA-DamID tracks of NL interactions across chromosome 9, control and recombined clones of recombination d5. Tracks were plotted using Integrated Genomics Viewer.
