Fig. 5: Multiple tethering elements within LAD2.
From: Interactions between the genome and the nuclear lamina are multivalent and cooperative
a, CAST allele-specific pA-DamID track of NL interactions in WT cells, together with the position of one loxP integration within LAD2 that was used in combination with the anchor loxP to generate rearrangements i10. b, Top: cartoon of a pA-DamID track of NL interactions of the CAST allele, to illustrate the i10 inversion, which divides LAD2 into two segments that are separated by a large iLAD region. The domainogram (middle) and pA-DamID tracks (bottom) of CAST allele NL interactions are shown, comparing nonrecombined cells (control, blue) to cells with inversion i10 (red). Data are plotted using the chromosomal coordinates of the inverted genome. Star, LAD2.1, which loses NL contacts upon recombination; arrowhead, LAD2.2-flanking iLAD sequences, which gain NL contacts upon recombination.
