Fig. 7: Signal integration at the Xist locus.
From: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Schematic depicting the regulatory logic at the Xist locus during random XCI. The X-chromosome number drives female-specific initiation of XCI through the activation of proximal REs by basal activators. The developmental state is additionally sensed by distal REs through boosting factors and promotes high Xist levels that are required for efficient gene silencing.
