Extended Data Fig. 1: Characterization of the genomic architecture in 2CLCs. | Nature Structural & Molecular Biology

Extended Data Fig. 1: Characterization of the genomic architecture in 2CLCs.

From: Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization

Extended Data Fig. 1

(a) Decay of intra-chromosomal contact probability as a function of genomic distance in ESCs (red) and 2CLCs (cyan). (b) Aggregate TAD positions annotated in ESCs and 2CLCS. (c) Aggregate over loop positions in ESCs and 2CLCS. (d) Saddle plots showing chromatin compartmentalization between 50 kb genomic bins ranked according to their eigenvector value (PC1) in ESCs and 2CLCs. (e) Example of Hi-C maps for full chromosomes 4, 6, and 8 (left) in ESCs and 2CLCs, along with a zoomed-in view of one end of their subtelomeric regions, opposite the centromere (right).

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