Fig. 3
From: Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds
Quality assessment of the LINCS signaling and epigenetics proteomics data library. (a) Correlation of replicates for experimental controls employed in the library. Boxplots show the distribution of Spearman correlation coefficients for replicates within the same plate, within the same cell line, and across all cell lines. Boxes indicate the extents of the 1st and 3rd quartile, while whiskers indicate 1.5x the interquartile range. (b) Distributions of all Spearman correlations among replicates (red) and among non-replicates (gray) across the whole dataset, with dashed lines representing the median of the distribution. (c) Bar chart showing the number of compounds considered reproducible in each cell line for each assay. The permutation test was run 10 times with 10,000 bootstrapped iterations; bars represent the average and error bars represent the standard deviation of the 10 runs.
