Fig. 3
From: Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis
Summary of the meta-analysis findings. Venn diagrams showing (a) the total number of identified proteins (with distinct protein IDs) shared between the labeled and the label-free datasets, and (b) the statistically significant proteins with FDR < 10% identified by the meta-analysis of the labeled and the label-free datasets. Despite a large overlap found between the two data subsets (3731 proteins), only 71 proteins were significantly altered in AD in both meta-analyses. The top 10 most significantly altered proteins were shown next to the Venn diagram. *These proteins were among the shared proteins. (c) Out of 71 significantly altered proteins, 33 were identified as the most robust changes in AD, since the direction of change remained the same across labeled and label-free datasets. Some of these proteins were found to be involved in synaptic signaling, apoptotic and proteasomal protein catabolic processes. Proteins that showed no statistically significant difference between AD and controls as well as the ones that were not identified in the original dataset are indicated by the white boxes.
