Online-only Table 1 Overview of the frequencies and descriptive statistics of all brain tumour types included in the DBTA.

From: The Digital Brain Tumour Atlas, an open histopathology resource

	# of scans	Median age	Age range	Cellularity	Tissue Area	F:M ratio	Most frequent location
Adamantinomatous craniopharyngioma	85	30 years	2–79 years	5219 ± 254/mm²	81 ± 7 mm²	1.36	sellar region
Anaplastic astrocytoma, IDH-mutant	47	43 years	24–65 years	3765 ± 282/mm²	162 ± 17 mm²	0.74	frontal
Anaplastic astrocytoma, IDH-wildtype	47	54 years	12–79 years	4633 ± 361/mm²	85 ± 14 mm²	0.57	temporal
Anaplastic ependymoma	50	7 years	0.3–77 years	5571 ± 298/mm²	138 ± 16 mm²	0.92	fourth ventricle
Anaplastic ganglioglioma	5	36 years	14–70 years	3129 ± 801/mm²	96 ± 44 mm²	NA	temporal
Anaplastic meningioma	46	63 years	30–84 years	6291 ± 380/mm²	223 ± 17 mm²	1.19	frontal
Anaplastic oligodendroglioma, IDH-mutant and 1p/19q codeleted	91	49 years	30–78 years	4899 ± 217/mm²	162 ± 11 mm²	0.72	frontal
Anaplastic pleomorphic xanthoastrocytoma	1	48 years	NA	2933/mm²	245 mm²	NA	cerebral, NOS
Angiocentric glioma	3	8 years	3–35 years	3519/mm²	138 mm²	2	temporal
Angiomatous meningioma	32	60 years	43–79 years	4185 ± 330/mm²	201 ± 14 mm²	1.13	frontal
Angiosarcoma	2	66 years	53–79 years	2440/mm²	112 mm²	NA	cerebral, NOS
Astroblastoma	7	40 years	12–83 years	5417 ± 440/mm²	120 ± 24 mm²	1.33	frontal
Atypical choroid plexus papilloma	4	26 years	0.3–56 years	6555/mm²	98 mm²	1	lateral ventricle
Atypical meningioma	83	58 years	13–92 years	6901 ± 222/mm²	225 ± 11 mm²	1.13	frontal
Atypical teratoid/rhabdoid tumour	17	3 years	0.3–10 years	6846 ± 791/mm²	61 ± 21 mm²	1.29	temporal
CNS ganglioneuroblastoma	1	0 years	NA	7247/mm²	306 mm²	NA	frontal
Cellular schwannoma	25	54 years	27–79 years	7459 ± 526/mm²	128 ± 20 mm²	1.08	spinal
Central neurocytoma	20	28 years	6–41 years	8053 ± 650/mm²	110 ± 22 mm²	0.67	lateral ventricle
Cerebellar liponeurocytoma	4	50 years	43–57 years	6924/mm²	125 mm²	NA	cranial nerves
Chondrosarcoma	21	37 years	6–73 years	5642 ± 621/mm²	132 ± 28 mm²	1.33	cranial, NOS
Chordoid glioma of the third ventricle	4	34 years	26–42 years	5074/mm²	36 mm²	0.33	third ventricle
Chordoid meningioma	12	47 years	35–73 years	4408 ± 776/mm²	210 ± 17 mm²	3	cranial, NOS
Chordoma	28	61 years	4–85 years	2808 ± 342/mm²	114 ± 16 mm²	0.56	cranial, NOS
Choriocarcinoma	1	76 years	NA	8954/mm²	131 mm²	NA	sellar region
Choroid plexus carcinoma	7	3 years	0.5–46 years	6778 ± 691/mm²	100 ± 35 mm²	NA	cerebral, NOS
Choroid plexus papilloma	21	29 years	0.2–78 years	5454 ± 467/mm²	156 ± 26 mm²	0.91	fourth ventricle
Clear cell meningioma	13	39 years	8–74 years	5027 ± 648/mm²	182 ± 32 mm²	1.17	sellar region
Crystal-storing histiocytosis	1	62 years	NA	1435/mm²	211 mm²	NA	NA
Desmoplastic infantile astrocytoma and ganglioglioma	11	1 years	0.5–23 years	5206 ± 642/mm²	180 ± 37 mm²	1.5	parietal
Diffuse astrocytoma, IDH-mutant	70	37 years	18–60 years	3013 ± 171/mm²	105 ± 12 mm²	0.64	frontal
Diffuse astrocytoma, IDH-wildtype	19	58 years	20–77 years	2730 ± 315/mm²	90 ± 23 mm²	0.36	frontal
Diffuse large B-cell lymphoma of the CNS	59	68 years	9–84 years	6021 ± 450/mm²	90 ± 13 mm²	1.46	frontal
Diffuse leptomeningeal glioneuronal tumour	1	2 years	NA	8070/mm²	8 mm²	NA	frontal
Diffuse midline glioma, H3 K27M-mutant	21	19 years	3–64 years	4258 ± 460/mm²	26 ± 7 mm²	1.1	brain stem
Dysembryoplastic neuroepithelial tumour	25	31 years	8–57 years	2410 ± 196/mm²	76 ± 16 mm²	0.79	temporal
Dysplastic cerebellar gangliocytoma	1	38 years	NA	2345/mm²	196 mm²	NA	cerebellar
EBV-positive diffuse large B-cell lymphoma, NOS	1	34 years	NA	6595/mm²	5 mm²	NA	frontal
Embryonal carcinoma	1	39 years	NA	4888/mm²	291 mm²	NA	parietal
Embryonal tumour with multilayered rosettes, C19MC-altered	3	2 years	2–3 years	6087/mm²	231 mm²	2	parietal
Ependymoma	46	49 years	2–78 years	4813 ± 347/mm²	94 ± 12 mm²	0.96	spinal
Ependymoma, RELA fusion-positive	6	12 years	4–55 years	5814 ± 1401/mm²	138 ± 40 mm²	0.5	lateral ventricle
Epitheloid MPNST	1	50 years	NA	3003/mm²	70 mm²	NA	other
Erdheim-Chester disease	1	57 years	NA	2194/mm²	239 mm²	NA	NA
Ewing sarcoma	4	6 years	0.8–28 years	8370/mm²	91 mm²	1	spinal
Extraventricular neurocytoma	1	36 years	NA	1193/mm²	107 mm²	NA	spinal
Fibrosarcoma	2	27 years	20–34 years	4639/mm²	199 mm²	1	cerebral, NOS
Fibrous meningioma	57	58 years	12–84 years	6103 ± 237/mm²	228 ± 13 mm²	6.12	cranial, NOS
Follicular lymphoma	3	62 years	62–64 years	8741/mm²	276 mm²	2	occipital
Gangliocytoma	1	36 years	NA	1127/mm²	10 mm²	NA	occipital
Ganglioglioma	88	21 years	2–65 years	2932 ± 153/mm²	110 ± 9 mm²	0.6	temporal
Ganglioneuroma	2	33 years	27–39 years	4228/mm²	212 mm²	1	other
Gemistocytic astrocytoma, IDH-mutant	6	38 years	29–56 years	2036 ± 228/mm²	121 ± 25 mm²	0.5	temporal
Germinoma	20	16 years	9–33 years	7091 ± 686/mm²	21 ± 6 mm²	0.11	diencephalon
Giant cell glioblastoma	21	43 years	11–86 years	3170 ± 301/mm²	181 ± 20 mm²	0.62	temporal
Glioblastoma, IDH-mutant	34	38 years	25–73 years	4867 ± 296/mm²	172 ± 19 mm²	1	frontal
Glioblastoma, IDH-wildtype	474	62 years	17–87 years	4481 ± 96/mm²	151 ± 5 mm²	0.66	temporal
Gliosarcoma	59	57 years	9–86 years	4794 ± 276/mm²	221 ± 14 mm²	0.44	temporal
Granular cell tumour of the sellar region	1	46 years	NA	2172/mm²	97 mm²	NA	sellar region
Haemangioblastoma	88	50 years	16–81 years	5119 ± 185/mm²	109 ± 10 mm²	1	cerebellar
Haemangioma	30	51 years	0.2–76 years	2796 ± 292/mm²	133 ± 15 mm²	2	cranial, NOS
Haemangiopericytoma	34	39 years	25–83 years	9064 ± 489/mm²	186 ± 18 mm²	0.48	cranial, NOS
Hybrid nerve sheath tumours	3	58 years	32–72 years	3342/mm²	227 mm²	0.5	spinal
Immature teratoma	7	15 years	0.0–56 years	7927 ± 913/mm²	107 ± 28 mm²	0.4	third ventricle
Immunodeficiency-associated CNS lymphoma	5	53 years	31–73 years	5209 ± 1227/mm²	65 ± 34 mm²	0.67	cerebral, NOS
Inflammatory myofibroblastic tumour	1	26 years	NA	5226/mm²	298 mm²	NA	frontal
Intravascular large B-cell lymphoma	2	70 years	62–78 years	1242/mm²	427 mm²	NA	NA
Juvenile xanthogranuloma	1	23 years	NA	12519/mm²	75 mm²	NA	NA
Langerhans cell histiocytosis	32	13 years	1–53 years	6848 ± 565/mm²	104 ± 19 mm²	0.78	parietal
Leiomyoma	1	50 years	NA	1864/mm²	28 mm²	NA	cranial, NOS
Leiomyosarcoma	4	58 years	50–77 years	6955/mm²	213 mm²	1	occipital
Lipoma	38	10 years	0.3–76 years	757 ± 66/mm²	120 ± 16 mm²	0.9	spinal
Liposarcoma	1	52 years	NA	2697/mm²	107 mm²	NA	spinal
Low-grade B-cell lymphomas of the CNS	13	67 years	50–83 years	8087 ± 1088/mm²	86 ± 25 mm²	1.17	spinal
Lymphoplasmacyte-rich meningioma	2	46 years	37–55 years	9817/mm²	37 mm²	1	cranial, NOS
MALT lymphoma of the dura	5	68 years	39–79 years	9843 ± 1672/mm²	39 ± 23 mm²	1.5	cranial, NOS
Malignant peripheral nerve sheath tumour	15	61 years	17–81 years	5886 ± 794/mm²	136 ± 28 mm²	0.88	spinal
Mature teratoma	6	10 years	0.2–49 years	3259 ± 760/mm²	135 ± 45 mm²	0.2	spinal
Medulloblastoma, SHH-activated and TP53-mutant	3	16 years	0.5–52 years	9539/mm²	117 mm²	2	cerebellar
Medulloblastoma, SHH-activated and TP53-wildtype	9	30 years	1–75 years	10544 ± 581/mm²	185 ± 38 mm²	0.5	cerebellar
Medulloblastoma, WNT-activated	7	13 years	6–65 years	7641 ± 954/mm²	79 ± 20 mm²	0.4	fourth ventricle
Medulloblastoma, non-WNT/non-SHH	32	8 years	3–34 years	8799 ± 412/mm²	113 ± 13 mm²	0.33	fourth ventricle
Melanotic schwannoma	3	64 years	51–69 years	3110/mm²	55 mm²	0.5	cranial nerves
Meningeal melanocytoma	5	51 years	35–54 years	8152 ± 1898/mm²	172 ± 60 mm²	0.67	spinal
Meningeal melanoma	2	61 years	51–71 years	6763/mm²	160 mm²	NA	spinal
Meningothelial meningioma	104	55 years	25–88 years	5951 ± 212/mm²	162 ± 10 mm²	4.47	cranial, NOS
Metaplastic meningioma	4	75 years	56–85 years	4613/mm²	226 mm²	NA	frontal
Metastatic tumours	47	58 years	38–78 years	5092 ± 399/mm²	159 ± 14 mm²	0.88	spinal
Microcystic meningioma	23	48 years	33–75 years	4475 ± 382/mm²	213 ± 23 mm²	2.83	frontal
Mixed germ cell tumour	5	20 years	12–44 years	4379 ± 1084/mm²	142 ± 45 mm²	0.25	spinal
Myxopapillary ependymoma	23	35 years	11–71 years	3188 ± 360/mm²	154 ± 16 mm²	0.64	spinal
Neurofibroma	16	44 years	0.7–65 years	3640 ± 446/mm²	151 ± 29 mm²	0.6	spinal
Olfactory neuroblastoma	10	58 years	27–69 years	5053 ± 780/mm²	213 ± 34 mm²	0.25	cranial, NOS
Oligodendroglioma, IDH-mutant and 1p/19q codeleted	85	46 years	12–73 years	3587 ± 174/mm²	136 ± 12 mm²	0.7	frontal
Osteochondroma	1	14 years	NA	2388/mm²	39 mm²	NA	spinal
Osteoma	9	48 years	40–69 years	1570 ± 638/mm²	107 ± 33 mm²	1.25	frontal
Osteosarcoma	8	30 years	17–54 years	4328 ± 498/mm²	176 ± 20 mm²	3	cerebral, NOS
Papillary craniopharyngioma	13	61 years	44–82 years	4941 ± 427/mm²	65 ± 13 mm²	0.86	sellar region
Papillary ependymoma	2	35 years	35–35 years	5573/mm²	146 mm²	NA	spinal
Papillary glioneuronal tumour	2	12 years	12–13 years	5877/mm²	117 mm²	NA	cerebral, NOS
Papillary meningioma	3	38 years	20–61 years	7270/mm²	198 mm²	NA	temporal
Papillary tumour of the pineal region	11	17 years	4–48 years	6094 ± 807/mm²	82 ± 28 mm²	1.75	third ventricle
Paraganglioma	17	54 years	25–69 years	6734 ± 468/mm²	165 ± 24 mm²	0.89	spinal
Perineurioma	1	23 years	NA	3580/mm²	26 mm²	NA	other
Pilocytic astrocytoma	173	11 years	0.6–51 years	3327 ± 117/mm²	105 ± 8 mm²	0.66	cerebellar
Pilomyxoid astrocytoma	24	7 years	0.4–56 years	4073 ± 362/mm²	45 ± 11 mm²	1	cranial nerves
Pineal parenchymal tumour of intermediate differentiation	6	44 years	9–55 years	9287 ± 619/mm²	86 ± 44 mm²	0.2	diencephalon
Pineoblastoma	5	23 years	1–67 years	7436 ± 1352/mm²	87 ± 43 mm²	4	third ventricle
Pineocytoma	6	19 years	1–40 years	4086 ± 1245/mm²	60 ± 38 mm²	0.5	diencephalon
Pituicytoma	3	47 years	27–67 years	5231/mm²	33 mm²	2	sellar region
Pituitary adenoma	99	54 years	16–80 years	7842 ± 225/mm²	56 ± 6 mm²	0.98	sellar region
Pleomorphic xanthoastrocytoma	21	29 years	5–72 years	4215 ± 368/mm²	145 ± 23 mm²	1.38	temporal
Plexiform neurofibroma	1	12 years	NA	12310/mm²	66 mm²	NA	NA
Psammomatous meningioma	28	66 years	29–83 years	5201 ± 372/mm²	125 ± 15 mm²	8.33	spinal
Rhabdoid meningioma	5	63 years	52–89 years	5016 ± 475/mm²	235 ± 62 mm²	0.67	occipital
Rhabdomyosarcoma	3	51 years	49–62 years	2474/mm²	299 mm²	2	cranial, NOS
Rosette-forming glioneuronal tumour	11	25 years	13–47 years	3997 ± 822/mm²	56 ± 21 mm²	1.75	cerebellar
Schwannoma	81	53 years	14–78 years	5715 ± 229/mm²	124 ± 10 mm²	0.93	cranial nerves
Secretory meningioma	41	58 years	40–80 years	6112 ± 313/mm²	154 ± 16 mm²	12.67	cranial, NOS
Spindle cell oncocytoma	1	47 years	NA	4958/mm²	13 mm²	NA	NA
Subependymal giant cell astrocytoma	14	15 years	10–33 years	3336 ± 447/mm²	136 ± 31 mm²	0.56	lateral ventricle
Subependymoma	24	54 years	8–81 years	1829 ± 151/mm²	125 ± 20 mm²	1.18	lateral ventricle
T-cell and NK/T-cell lymphomas of the CNS	1	54 years	NA	7400/mm²	18 mm²	NA	cerebral, NOS
Tanycytic ependymoma	1	41 years	NA	5440/mm²	232 mm²	NA	spinal
Teratoma with malignant transformation	1	40 years	NA	7202/mm²	122 mm²	NA	frontal
Transitional meningioma	68	58 years	29–82 years	7221 ± 213/mm²	203 ± 13 mm²	2.09	frontal
Undifferentiated pleomorphic sarcoma	1	62 years	NA	5773/mm²	401 mm²	NA	cranial, NOS

Cellularity and Tissue area are given as [mean ± SEM].

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Online-only Table 1 Overview of the frequencies and descriptive statistics of all brain tumour types included in the DBTA.

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