Fig. 6
From: High resolution optical mapping of cardiac electrophysiology in pre-clinical models
Ischaemia induced conduction slowing and action potential shortening in mouse whole hearts. (a) Example activation maps from mouse whole heart in before (black), during (blue, ischaemia) and after (red, reperfusion) low-flow ischaemia. (b) Grouped conduction velocity data from mouse whole heart in control, ischaemia and reperfusion conditions. (c) Example action potential duration 80 (APD80) maps from mouse whole heart at baseline (black), during (blue, ischaemia) and after (red, reperfusion) low-flow ischaemia. (d) Grouped APD80 data from mouse whole heart in control, ischaemia, and reperfusion conditions. n = 12. One-way ANOVA, *P < 0.05, **P < 0.01. ****P < 0.0001. Multiple comparisons are made between all groups (Baseline, Ischaemia, Reperfusion). Pacing cycle length = 110 ms.
