Fig. 5
From: Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition
Validation of key senescence markers in total proteome and phosphoproteome. (a) Log2FC of cyclins significantly differentially expressed in Palbociclib-treated MDA-MB-231 cells, both FBS and starved samples, versus their respective DMSO controls. Log2FC was calculated using a one sample t-test and subsequent results were filtered for q-value < 0.05 using Perseus software39. (b) Heatmap of phosphorylation sites of RB1 (pRB) showing a decrease in RB1 phosphorylation at multiple sites after Palbociclib treatment.Log2FC = Log2 Fold Change.
