Fig. 1

Single cell expression atlas of IS, HS and AD. (A) The overall analysis workflow of this study. (B,C) Uniform manifold approximation and projection (UMAP) plot for cell types and sample groups. WT_sc, Wild type with single cell sequencing. WT_sn, Wild type with single nucleus sequencing. (D) Dot plot displaying the average scRNA-seq expression of selected marker genes across all detected cell types (normalized to a scale of 0–2). E. Proportion of cells of each cell type (x axis) detected with different groups (y axis).