Fig. 2
From: Analysis of AlphaMissense data in different protein groups and structural context
Symmetries of AlphaMissense amino acid substitutions. (a) Mean AlphaMissense scores for variations, which display a minimum score difference of 0.2 when compared to the reverse amino acid change. Asterisks mark those changes which get the opposite label (benign/pathogenic) in the case of reverse change. (b) Mean AlphaMissence scores for each variation grouped by their BLOSUM62 score. Dashed and dashed dotted lines indicate the cutoffs of the ambiguous AlphaMissense predictions. Solid back line was fitted (r = −0.678, p = 6.39 × 10−27). Orange circles: amino acid substitutions possible with single nucleotide change; blue circles: all other substitutions.
