Fig. 4
Utility of endogenous protein quantification in tissues and plasma. (a) A panel of frozen tissues was obtained for 77 tumors from 11 tumor types. The pie chart shows the number of each type. (b) Histogram of peptide detection, showing the number of peptides detected above LLOQ across the 77 frozen tumors. (c) A panel of plasma samples was obtained from 48 patients with breast, colorectal, or ovarian tumors, as indicated in the pie chart. (d) Histogram of peptide detection, showing the number of peptides detected above LLOQ across the 48 plasma samples. (e) Bar plot showing the number of analytes predicted to be above the LLOQ for decreasing amounts of input tissue lysate. Detection prediction was extrapolated from the signal-to-noise ratio measured in (b). Error bars show the 95% confidence interval.
