Fig. 2
From: An integrated analysis of multiple datasets reveals novel gene signatures in human granulosa cells
Analysis and comparison of enriched GO terms for DEGs. (a) Dotplot shows enriched GO terms over the 3 BioProjects, highlighting the first twelve most significantly over-represented GO terms in biological processes. The x-axis reports the Bioproject name and the n. of DEGs involved in those GO processes reported in parenthesis. The y-axis shows significantly enriched GO terms. The size of each dot indicates the number of genes associated with that GO term in the respective cluster (gene count). The color scale represents the adjusted p-value, with darker colors indicating higher statistical significance. Only GO terms with an adjusted p-value < 0.05 are shown. (b) Upset plot of the intersection of DEGs across BioProjects. The horizontal bar graph on the left shows the total number of DEGs for each BioProject. The upper black bar graphs show the number of DEGs for each overlapping combination and black connected dots indicate which BioProjects are involved in each intersection. Plot shows the number of shared DEGs among 3 Bioprojects (n = 236, herein defined as “core set”), among at least two BioProjects (n = 390, 521 and 1229) and BioProject-specific (n = 1095, 1236 and 5267). (c) PPI network of the core set of 236 shared DEGs. The network nodes represent proteins. Colored nodes highlighted in red (n = 160) are proteins known to be involved in “Alternative splicing” with a great statistical significance (p-adj < 0.05).
