Fig. 15

Validation through shortest path analysis. Analysis of connections between HPO terms in a Petagraph subgraph between abnormal central nervous system (CNS) morphology and CNS neoplastic processes (a) An example Petagraph subgraph consisting of shortest paths connecting 54 abnormal CNS morphology and 54 CNS neoplasms, containing a total of 777 nodes including 191 human genes. Colors reflect the edge traversal counts and node degree centralities. (b) Node degree histogram of the subgraph. (c) Edge traversal count frequencies for the subgraph. (d) Shortest path length distribution of the subgraph.