Table 2 Summary of availability of clinical metadata stratified by source brain bank.

From: A multi-region single nucleus transcriptomic atlas of Parkinson’s disease

Table Name

Description

Brain Bank

Ref [PMID]

UD

HA

UM

MS

PD Medical History

initiation and use of PD medication, changes of diagnosis over time, indication of surgeries

X

X

X

X

 

Family History PD

indication of PD diagnosis for father, mother and/or other relatives

X

 

X

  

Smoking and alcohol history

indication and quantification of severity of smoking and alcohol consumption

X

 

X

X

 

Epworth Sleepiness Scale

general level of daytime sleepiness

X

   

1798888

LBD_Cohort_Clinical_Data

clinical symptoms (e.g. visual hallucionations, loss of memory, mood disorder)

X

X

X

X

 

LBD_Cohort_Path_Data

neuropathological assessments (CERADa, AD Braak, PD Braak)

X

X

X

X

 

MDS UPDRSb Part I

non-motor symptoms covering aspects like mood, cognition and sleep

X

   

12815652

MDS UPDRSb Part II

motor symptoms impacting daily activities

X

 

X

 

12815652

MDS UPDRSb Part IV

motor complications related to PD disease treatment

X

   

12815652

MMSEc

screening for cognitive impairment and monitoring fo changes in mental status over time

X

 

X

 

1202204

Modified Schwab & England (ADLd)

assessment of the capabilities of people with impaired mobility

X

    

UPDRSb

other UPDRS metrics not involved in Part I-IV

X

   

12815652

  1. aCERAD: Consortium to Establish a Registry for Alzheimer’s Disease.
  2. bMDS UPDRS: Movement Disorder Society – Unified Parkinson’s Disease Rating Scale.
  3. cMMSE: Mini Mental State Examination.
  4. dADL: Activities of Daily Living.
  5. Complete description of all metrics at https://amp-pd.org/harmonized-clinical-assessments.