Figure 1

Discovery of a prognostic ion gene in gliomas. (A) Schematic strategy used to identify a prognostic ion gene in gliomas. (B) The qRT-PCR analysis of relative KCNB1 expression in glioma tissue samples from the validation cohort. P values were calculated with two-sided Student’s t test. (C,D) Kaplan–Meier OS and PFS analysis of patients with high grade (83 patients with primary GBM and 41 patients with grade III) in CGGA. Survival among KCNB1-high group (n = 62) and KCNB1-low group (n = 62) patients is shown. P values were calculated using the two-sided log-rank test. (E,F) Kaplan–Meier OS analysis of patients with high grade in GSE16011 (154 patients with grade IV and 84 patients with grade III) and REMBRANDT (110 patients with grade IV and 71 patients with grade III). OS, overall survival; PFS, progression-free survival. P values were calculated with a two-sided log-rank test.