Figure 5

Immunosenescence predicts accelerated disease progression in old ChRM. (a) Old ChRM have a significantly lower frequency of naïve CD4⁺and CD8⁺ T cells and naïve B cells than young ChRM before infection. P values were determined using the Mann-Whitney t-test. (b) The correlation matrix constructed by package corrplot with R reveals the relationships between the markers of immunosenescence and SIV disease progression during infection. (c) The correlation matrix reveals the relationships between characteristic values before and after infection. Pre, value before infection; Peak, peak value during infection; Nadir, minimum value during infection. The blue and red indicate positive and negative correlations, respectively (see color bar). The results of Spearman’s test (two-tailed, unadjusted) with a P value ≥ 0.05 were considered not significant (shown as cross).