Figure 2 | Scientific Reports

Figure 2

From: Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities—an analysis of CRISPR genome-edited mouse embryos

Figure 2

Eye phenotypes of Pax6-CRISPR founder mice at E16.5. (a–d) Lateral view of the eye on the right side. (a) Wild-type eye. Based on stereomicroscopic observations, we categorized the eyes into three phenotype classes: class 1 (b) class 2 (c) and class 3 (d). (e) HE-stained coronal sections of wild-type eye. The retina has differentiated to form the inner neuroblastic layer. ir, iris; le, lens; nr, neural retina; on, optic nerve; rpe, retinal pigmented epithelium. Scale bars: 100 μm.

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