Figure 7
From: CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells
Simulation of electrical activity in alpha cells after introduction of CFTR. (A) Electrical activity was simulated using the model of Watts and Sherman7 with gKATP = 0.200 nS (=6 mM glucose3), gL = 0.200 nS and with gCFTR = 0.100 nS. Gray bar indicate CFTR inhibition. (B) As in A but gKATP = 0.270 nS (=1 mM glucose3) and gL = 0.150 nS35. (C) As in A but with gKATP = 0.300 nS (within experimental range at 1 mM glucose according to ref. 3).
