Figure 4
From: A Biologically-validated HCV E1E2 Heterodimer Structural Model
E1E2 heterodimer model. E1 and E2 structures are represented in cartoon and colored in blue and red, respectively. E2 HVR1, Ig-like domain and CD81bs are colored in purple, orange and green, respectively. Glycosylations are in licorice representation. (A) Overview of the entire, fully-glycosylated structure. (B) Details of E1, E1-E2 interfaces and the protective role of the variable regions HVR2 and IgVR on E1. These domains are depicted in solid colors, while the remaining E2 segments are transparent. (C) Protective role of HVR1 on CD81bs. Residues included in the CD81bs, Ig-like domain and HVR1 are in solid colors, all other regions are transparent. (D) Structural alignment of the E2c structured portions and the E1E2 model. 4MWF structure is aligned to the same regions of the model and colored in solid yellow. Model domains not superimposed to 4MWF are transparent. Glycosylations were removed for clarity.
