Figure 6

E1 disulfide isomerization. E1 β-sheets structure in the native conformation is depicted in cartoon and colored according to residue position (red residues are located at the N-terminal, blue residues at the C-terminal) to highlight long-range β-strand coupling. Cysteines are represented in licorice and colored according to the scheme. In the three boxes, cysteine coupling in native conditions and after the first and second disulfide isomerization steps are represented. Continuous lines connecting each cysteine represent disulfide bridges, while dashed lines highlight proximal cysteines in the linear sequence.