Figure 2
From: High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy
Differences in the transgene expression levels predict biological effects of the transgene. The biological effect of hVEGF-A was seen as enlarged sinusoid area in the liver (A,B,C) and capillary area in the heart (A,D,E). The decrease in the sinusoid area was significant after a HFD compared to RCD in LDLR−/−ApoB100/100 and LDLR−/− mice (C) and in the heart capillary area in LDLR−/− mice (E). Representative pictures from endothelium-stained sections of AdVEGF-A transduced livers (B) and heart (D). Scale bars 50 µm, N = 4, sinusoid and capillary area analyzed from five microscopic fields/mouse. Fold increase is shown above compared columns in panel A.
