Figure 4
From: High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy
Proposed mechanism on how lipoproteins and lipoprotein receptors are affecting Ad transduction in different hyperlipidemic mouse models. There are three possible routes for Ad entry into the cells: LDLR, LRP and HSPG. High lipoprotein levels in hyperlipidemic mice on a HFD are competing with the Ad uptake via these different routes leading to a decreased transgene expression compared to C57Bl/6j mice. In apoE-deficient mice this competition with Ad uptake is not as efficient as in LDLR-deficient mice due to absence of apoE which mediates lipoprotein binding to LRP.
